Scientists have discovered new genes that trigger muscle loss, shedding light on treatment methods for sarcopenia in particular among elderly individuals. Analysis of genetic data using artificial intelligence revealed that the USP54 gene plays a significant role in muscle weakness. These findings could assist in developing exercise-based interventions to preserve muscle mass in the elderly. Researchers have identified new genes playing a key role in the process of muscle loss.

A collaborative study between the Karolinska Institute and Karolinska University Hospital in Sweden and Anglia Ruskin University in the UK presents new information about genes that trigger muscle loss. The researchers announced new findings that could impact treatments related to this process for elderly individuals with sarcopenia.

Physical exercise emerges as the recommended method to prevent muscle weakness and sarcopenia. In the study, genetic expression data of individuals aged 21-43 and 63-79 were analyzed. Using artificial intelligence, the first 200 genes interacting with aging and exercise were identified. In particular, it was found that the USP54 gene plays a critical role in muscle weakness and loss in elderly individuals.

Dr. Lívia Santos from Nottingham Trent University expressed their goal to identify genes that could delay the effects of aging, stating, “Muscle loss is a major problem. It increases the risk of falls and the likelihood of developing physical impediments. Understanding the mechanisms regulating muscle weakness is an urgent need.” Researcher Dr. Janelle Tarum highlighted the potential provided by artificial intelligence in sarcopenia research, indicating that discovering new genes will contribute to studies in this field.

The findings of the study are considered an important step in developing more informed exercise interventions to preserve muscle mass in elderly individuals.